What distinguishes this from a run-of-the-mill disease-of-the-month tearjerker from Lifetime Movie Network? Easy, pilgrim: the answer is Mr. Matthew McConaughey. He's a force of movie nature when he wants to be.
Here, Mr. McConaughey plays Ron Woodruff. It's the early 80's and Woodruff is a hard-charging redneck Texas non-homosexual, but unfortunately he's into a lot of other risky behavior, like drug use and unprotected sex. So he finds himself with AIDS, and the doctor gives him 30 days to live.
Woodruff also mixes cocaine with AZT, recipe for dying sooner than 30 days. He finds himself in a Mexican clinic, where an unlicensed doc makes him feel better with unapproved drugs. Which gets Ron's humanitarian/entrepreneurial juices flowing: why, if he takes this stuff up to Texas, he could make some serious money. Only problem being, it's probably only slightly less legally risky to sell FDA-unapproved medications than it is to deal in cocaine and heroin.
Of course, Ron "grows" out of his previous homophobia once he develops face-to-face relationships with his gay clientele. He also wins over Jennifer Garner, a doctor initially by-the-book, gradually becoming more humanitarian.
The movie is intensely libertarian, making a strident case against the lengthy and bureaucratic FDA process for declaring a drug "safe and effective". In the meantime people are dying. But another (unfortunate) theme strongly implies corruption between the FDA, Big Pharma, and the local doctors who stand to make a bundle off AZT.
It's a nice story, but there's a contrary take at the Washington Post that makes it difficult to buy the movie's medical basis.