This book is a sequel to Bloodsucking Fiends, which I read back in 2011. Some sequels stand OK on their own, but (consumer note) I would recommend reading this series in order. Unless your memory for plot details is better than mine, I wouldn't recommend waiting over five years between reading the two, either.
At the end of the previous book, vampire Jody had "turned" her Renfield, young aspiring writer C. Thomas Flood, and as this book begins, he's pretty peeved about that. But that only lasts about three paragraphs, because being a vampire in San Francisco does have its advantages. But the logistical details are daunting. You need to keep track of sunrise times, lest you be burnt to a crisp. And there's the need to feed, which is problematic if you have scruples about killing people. Plus, your old buddies on the night shift at Safeway were useful allies in combatting Jody's old mentor, Elijah. But now you're perceived as part of the problem. Elijah (as it turns out) wasn't totally defeated in the previous book. And two corrupt cops are hovering around as well.
There are a few new characters: "Abby Normal" is a profane young teenage Goth, who gets recruited to assist. And there's also "Blue", a hooker imported from Vegas by the non-vampire Safeway workers, who have quickly blown their ill-begotten windfall from the previous book on her.
Moore is, as usual, hilarious and filthy, with a core of sweetness. I keep wondering if they'll ever manage to make a movie or TV series out of his books. Much of the humor is in his prose, though, so I'm not sure how well it would work.